M4K-2009

CAT: 0804-HY-149591Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149591Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M4K-2009 is an BBB-penetrant inhibitor of ALK2 with an IC50 of 13 nM. M4K-2009 is an analogue of LDN-214117 (HY-16712) . M4K-2009 is also active against the hERG potassium channel[1][2][3].
CAS Number
[2600795-07-9]
UNSPSC
12352005
Target
TGF-β Receptor
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC(C=C1C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)=C(C(OC)=C1)OC
Molecular Formula
C25H29N3O3
Molecular Weight
419.52
References & Citations
[1]González-Álvarez, H., et al., (2024) . Discovery of Conformationally Constrained ALK2 Inhibitors. Journal of medicinal chemistry, 67 (6), 4707-4725. |[2]Ensan, D., (2020) . Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of medicinal chemistry, 63 (9), 4978-4996.|[3]Smil, D., (2020) . Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of medicinal chemistry, 63 (17), 10061-10085.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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