2002-H20

CAT: 0804-HY-116942Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-116942Size:1 Each
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Description
2002-H20 is an inhibitor of Aβ42-induced cytotoxicity, with the activity of reducing the cytotoxicity of Alzheimer's disease Aβ peptide by binding to it. 2002-H20 protects cells and reduces Aβ toxicity by promoting fibril formation, possibly by accelerating Aβ aggregation. The screening method of 2002-H20 effectively identifies compounds that reduce Aβ toxicity and presents potential inhibitory leads[1].
CAS Number
[351520-91-7]
UNSPSC
12352005
Hazard Statement
H319
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2002-h20.html
Smiles
O=C(C1=CC=C(C=C1)N)NC2=CC=C(C(C3=NC4=CC=CC=C4O3)=C2)O
Molecular Formula
C20H15N3O3
Molecular Weight
345.35
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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