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IMG-2005

CAT: 0804-HY-P10718Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10718Size:1 Each
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Description
IMG-2005 is a TLR signaling pathway inhibitor. IMG-2005 mimics the Toll/interleukin-1 receptor (TIR) domain of MyD88, thereby preventing its homodimerization, which causes damage to tracheal epithelial cells and triggers pulmonary immune diseases[1][2].
CAS Number
[1229954-79-3]
UNSPSC
12352209
Target
Toll-like Receptor (TLR)
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/img-2005.html
Smiles
O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(O)=O)[C@H](O)C)=O)=O)[C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC2=CNC3=CC=CC=C23)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C140H227N45O33S
Molecular Weight
3100.65
References & Citations
[1]Newkirk MM, et al. Chronic smoke exposure induces rheumatoid factor and anti-heat shock protein 70 autoantibodies in susceptible mice and humans with lung disease. Eur J Immunol. 2012 Apr;42 (4) :1051-61. |[2]Giangreco A, et al. Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance. J Pathol. 2011 Jun;224 (2) :190-202.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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