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ROCK2-IN-13

CAT: 0013-GTR19274170-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274170-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK2-IN-13 is a selective inhibitor of ROCK2. It functions by hindering ROCK2 kinase activity and reducing its nuclear expression, consequently disrupting the interaction between ROCK2 and transcription co-activators p300 and PGC 1α, thereby suppressing oncogene transcription. ROCK2-IN-13 activates FOXO1-driven PTEN expression, which in turn inhibits the PI3K/Akt pathway, induces G2/M cell cycle arrest, and promotes apoptosis (apoptosis) . This compound effectively eliminates the nuclear transcription function of ROCK2 that maintains oncogenic signaling and restores the tumor-suppressive PTEN/FOXO1 axis. ROCK2-IN-13 is utilized in prostate cancer research.
Storage Conditions
-20°C
Notes
For research use only.

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