Products for Research Use Only
RegisterLogin

JAK1-IN-17

CAT: 0804-HY-16641Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-16641Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM) . JAK1-IN-17 can be studied in cancer research[1].
CAS Number
1315490-71-1
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
N#C[C@H]1CC[C@H](N2C([C@H](O)C)=NC3=CN=C(NC=C4)C4=C32)CC1
Molecular Formula
C17H19N5O
Molecular Weight
309.37
References & Citations
[1]Mark Zak, et al., Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. J. Med. Chem. 2013, 56, 11, 4764–4785.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-176793JAK1-IN-18
HY-153568-01JAK1-IN-11
HY-144440JAK1-IN-9
HY-161139JAK1-IN-14
HY-153566JAK1-IN-10
HY-169242JAK1-IN-16
HY-161015-01JAK1-IN-13
HY-139423-01JAK1-IN-8
HY-149296JAK1-IN-12
HY-178282JAK1-IN-19

Alternative Products

CatalogName
T212341-01JAK1-IN-17
321249-01JAK1
abx402135-01Tyrosine-protein kinase JAK1 (JAK1) Antibody
GTR18338353Phospho-JAK1/JAK1 Rabbit Monoclonal Antibody
037176Jak1, NT (Jak1, Tyrosine-protein kinase JAK1, Janus kinase 1)

Popular Products