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SMU-L11-R

CAT: 0804-HY-179047Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179047Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMU-L11-R is a selective TLR7 agonist with an EC50 of 0.012 μM for human TLR7. SMU-L11-R specifically activates TLR7, recruits  MyD88, and triggers MAPK/NF-κB pathways, leading to TNF-α/IL-1β/IL-6 secretion in both mouse and human peripheral blood mononuclear cells. SMU-L11-R promotes M1-like macrophage polarization. SMU-L11-R exhibits excellent synergistic anti-tumor effects with PD-L1 inhibitors by upregulating CD8+T cells. SMU-L11-R shows potential in colorectal cancer studies[1].
CAS Number
3040320-18-8
Target
ERK; IKK; Interleukin Related; MyD88; p38 MAPK; TNF Receptor; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3C[C@@H]4COCC4
Molecular Formula
C19H24N4O
Molecular Weight
324.42
References & Citations
[1]Pan Y, et al. Imidazoloquinoline optical isomers as TLR7 selective agonists promote macrophage activation for cancer immunotherapy. Bioorg Chem. Published online October 13, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8

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