SMU-14a

• Target:

  TLR|||I?B/IKK|||NF-?B|||p38 MAPK|||ERK|||TNF

• Related Pathways:

  NF-?B|||Immunology/Inflammation|||MAPK|||Apoptosis

• Bioactivity:

  SMU-14a is a TLR3 inhibitor with an IC50 of 0.18 µM. It suppresses IL-6 secretion in mouse peritoneal macrophages and downregulates TNF-? in human peripheral blood mononuclear cells. The compound exerts anti-inflammatory effects by reducing the phosphorylation of p65, ERK, and TBK1 via the NF-?B, MAPK, and IRF3 signaling pathways, and by lowering serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) . SMU-14a is applicable in acute hepatitis research.

• Molecular Formula:

  C24H20N4O

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C