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ROCK2-IN-12

CAT: 0013-GTR19273594-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273594-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK2-IN-12 (Compound A25) is a selective inhibitor of ROCK2, exhibiting an IC50 of 7.0 nM for ROCK2, demonstrating greater efficacy compared to ROCK1 inhibition. It exerts potent anti-fibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. In a Bleomycin-induced mouse pulmonary fibrosis (PF) model, ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrosis progression. This compound is applicable in research on pulmonary diseases such as lung fibrosis.
CAS Number
3086603-12-2
Smiles
FC1=CC=C (C=C1) CNCC2=NC (=NO2) C3=CN=C4C=CC (=NN43) NC=5C=CC=6NN=CC6C5
Molecular Formula
C23H18FN9O
Molecular Weight
455.46
Storage Conditions
-20°C
Notes
For research use only.

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