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ALV-05-151-02

CAT: 0804-HY-178700Size: 1 EachDry Ice: NoHazardous: No
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Description
ALV-05-151-02 is a BLC6/BLC6B degrader. ALV-05-151-02 depletes endogenous BCL6 levels in SuDHL4 cells (high BCL6 expression) and BCL6B levels in KYO1 cells (high BCL6B expression) . ALV-05-151-02 can be used for the study of hematological malignancies[1].
CAS Number
2744249-11-2
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Cancer
Smiles
CN(C)C(CC(NC1=CC=CC(C(F)(F)F)=C1)=O)C2=CC(NC3=CCN(C4C(NC(CC4)=O)=O)C3=O)=CC=C2
Molecular Formula
C27H28F3N5O4
Molecular Weight
543.54
References & Citations
[1]Słabicki M, et al. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 2025 Aug 21;85 (16) :3184-3201.e14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3-(dimethylamino)-3-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]-N-[3-(trifluoromethyl)phenyl]propanamide
CAS Number2744249-11-2
PubChem CID166855550
IUPAC Name3-(dimethylamino)-3-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]-N-[3-(trifluoromethyl)phenyl]propanamide
Molecular FormulaC27H26F3N5O5
Molecular Weight557.5
XLogP2
Topological Polar Surface Area128
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Heavy Atom Count40
Formal Charge0
Complexity1060
SMILES
CN(C)C(CC(=O)NC1=CC=CC(=C1)C(F)(F)F)C2=CC(=CC=C2)NC3=CC(=O)N(C3=O)C4CCC(=O)NC4=O
InChI
InChI=1S/C27H26F3N5O5/c1-34(2)21(14-23(37)32-18-8-4-6-16(12-18)27(28,29)30)15-5-3-7-17(11-15)31-19-13-24(38)35(26(19)40)20-9-10-22(36)33-25(20)39/h3-8,11-13,20-21,31H,9-10,14H2,1-2H3,(H,32,37)(H,33,36,39)
InChIKey
NJZCHKLYBWDGQO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(dimethylamino)-3-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]-N-[3-(trifluoromethyl)phenyl]propanamide
CAS: 2744249-11-2
CID: 166855550
Formula: C27H26F3N5O5
MW: 557.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight557.5
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass557.18860343
Monoisotopic Mass557.18860343
Topological Polar Surface Area128 Ų
Heavy Atom Count40
Formal Charge0
Complexity1060
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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