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ALV-05-077-01

CAT: 0804-HY-178683Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178683Size:1 Each
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Description
ALV-05-077-01 is a BLC6/BLC6B degrader. ALV-05-077-01 depletes endogenous BCL6 levels in SuDHL4 cells (high BCL6 expression) and BCL6B levels in KYO1 cells (high BCL6B expression) . ALV-05-077-01 can be used for the study of hematological malignancies[1].
CAS Number
2438125-72-3
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Cancer
Smiles
O=C1C=C(C(N1C2C(NC(CC2)=O)=O)=O)NC3=CC=CC(CCC(NC4=CC=CC(C(F)(F)F)=C4)=O)=C3
Molecular Formula
C25H21F3N4O5
Molecular Weight
514.45
References & Citations
[1]Słabicki M, et al. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 2025 Aug 21;85 (16) :3184-3201.e14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]-N-[3-(trifluoromethyl)phenyl]propanamide
CAS Number2438125-72-3
PubChem CID146628310
IUPAC Name3-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]-N-[3-(trifluoromethyl)phenyl]propanamide
Molecular FormulaC25H21F3N4O5
Molecular Weight514.5
XLogP2.4
Topological Polar Surface Area125
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count37
Formal Charge0
Complexity982
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C=C(C2=O)NC3=CC=CC(=C3)CCC(=O)NC4=CC=CC(=C4)C(F)(F)F
InChI
InChI=1S/C25H21F3N4O5/c26-25(27,28)15-4-2-6-17(12-15)30-20(33)9-7-14-3-1-5-16(11-14)29-18-13-22(35)32(24(18)37)19-8-10-21(34)31-23(19)36/h1-6,11-13,19,29H,7-10H2,(H,30,33)(H,31,34,36)
InChIKey
JBYCFBDRJGATQY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]-N-[3-(trifluoromethyl)phenyl]propanamide
CAS: 2438125-72-3
CID: 146628310
Formula: C25H21F3N4O5
MW: 514.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight514.5
XLogP32.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass514.14640427
Monoisotopic Mass514.14640427
Topological Polar Surface Area125 Ų
Heavy Atom Count37
Formal Charge0
Complexity982
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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