Products for Research Use Only
RegisterLogin

JBJ-02-112-05

CAT: 0804-HY-135914Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-135914Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 15 nM for EGFRL858R/T790M[1].
CAS Number
2748162-29-8
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jbj-02-112-05.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC=CS1)C(N2C(C(C=C(C3=CC(C=CN4)=C4C=C3)C=C5)=C5C2)=O)C6=CC=CC=C6
Molecular Formula
C27H20N4O2S
Molecular Weight
464.54
References & Citations
[1] To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9 (7) :926-943.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

Related Products

CatalogName
HY-135805JBJ-04-125-02
HY-135805A(Rac) -JBJ-04-125-02
HY-135805B-01(Rac) -JBJ-04-125-02 (acetate)
HY-178700ALV-05-151-02
HY-151048-01JBJ-07-149
HY-147183JBJ-09-063
HY-147183A-01JBJ-09-063 (TFA)
HY-164487JBJ-08-178-01
HY-147183B-01JBJ-09-063 (hydrochloride)
HY-101045-01AT-112

Alternative Products

CatalogName
T11713-01JBJ-02-112-05
MBS5797148JBJ-03-142-02
GTR19157961-01JBJ-04-125-02
BUP03674-01(Rac) -JBJ-04-125-02
MBS5765027(Rac)-JBJ-04-125-02

Popular Products