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RIPK1-IN-34

CAT: 0013-GTR19273584-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273584-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK1-IN-34 is a selective RIPK1 inhibitor capable of penetrating the blood-brain barrier with an IC50 of 126.70 nM, showing minimal inhibition of RIPK3 (IC50 > 10,000 nM) . It exerts significant neuroprotective effects by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) in the necroptosis pathway. RIPK1-IN-34 demonstrates neuroprotective effects in rat models of middle cerebral artery occlusion (MCAO) and is a candidate for research in the treatment of acute ischemic stroke (AIS) .
CAS Number
3065634-19-4
Smiles
C (N[C@@H] (C) C1=CC=CC=C1) (=O) C=2C3=C (C=CC (=C3) C4=CC=5N (C=C4) N=C (NC (=O) C6CC6) N5) N=C (C) N2
Molecular Formula
C28H25N7O2
Molecular Weight
491.56
Storage Conditions
-20°C
Notes
For research use only.

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