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BChE-IN-44

CAT: 0013-GTR19273295-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273295-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BChE-IN-44 is a potent and highly selective butyrylcholinesterase (BChE) inhibitor that can penetrate the blood-brain barrier, demonstrated by [equineBChEIC50= 18.00 pM, humanBChEIC50= 1.50 nM]. BChE-IN-44 offers neuroprotective effects against Aβ1-42-induced damage models and halts the self-aggregation of Aβ1-42. It reduces levels of inflammatory factors (NO, IL-6, and TNF-α) in BV2 cells induced by lipopolysaccharides. Additionally, BChE-IN-44 significantly ameliorates cognitive impairment caused by scopolamine. It also regulates BChE and acetylcholine levels in the hippocampus of mice. BChE-IN-44 is applicable for Alzheimer's disease (AD) research.
Storage Conditions
-20°C
Notes
For research use only.

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