SKLB-0124

• Description:

  SKLB-0124 is a selective PRMT6 degrader with DC50s of 15.4 μM and a 16.4 μM in HCC827 and MDA-MB-435 cells. SKLB-0124 does not degrade PRMT1 or PRMT8. SKLB-0124 exhibits an IC50 on PRMT6 of 1.6 μM. SKLB-0124 induces proteasome dependent degradation of PRMT6 and significantly inhibits the proliferation. SKLB-0124 effectively induces apoptosis and cell cycle arrest. SKLB-0124 can be used for the studies of lung cancer and breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Histone Methyltransferase

• Related Pathways:

  Apoptosis; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=C (NCCCC (NC1=CC=C (C2=CN=CC (CN (C) CCNC) =C2) C=C1) =O) CC34C[C@H] (C[C@@H]5C4) C[C@H] (C5) C3

• Molecular Formula:

  C32H45N5O2

• Molecular Weight:

  531.73

• References & Citations:

  [1]Yang H, et al. Discovery of a first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) . Bioorg Chem. 2024 Jul;148:107439.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PRMT6

• CAS Number:

  3065966-31-3