SKLB-0266

• Description:

  SKLB-0266 is the negative control of SKLB-0124 (HY-178114) (a PRMT6 inhibitor) . SKLB-0266 after undergoing methylation modification completely loses its inhibitory activity against PRMT6[1].

• UNSPSC:

  12352005

• Target:

  Drug Derivative

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Smiles:

  O=C(NCCCC(NC1=CC=C(C2=CN=CC(CN(C)CCN(C)C)=C2)C=C1)=O)CC34C[C@H](C[C@@H]5C4)C[C@H](C5)C3

• Molecular Formula:

  C33H47N5O2

• Molecular Weight:

  545.76

• References & Citations:

  [1]Yang H, et al. Discovery of a first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) . Bioorg Chem. 2024 Jul;148:107439.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported