SKLB-11A

• Description:

  SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A) -induced cardiotoxicity and myocardial ischemia/reperfusion models[1].

• UNSPSC:

  12352005

• Target:

  Autophagy; Sirtuin

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cardiovascular Disease

• Purity:

  99.40

• Solubility:

  DMSO : 7.78 mg/mL (ultrasonic)

• Smiles:

  COC (C1=C (N) N (CC2=CC=C (F) C=C2) C3=NC4=CC=CC=C4N=C31) =O

• Molecular Formula:

  C19H15FN4O2

• Molecular Weight:

  350.35

• References & Citations:

  [1]Zhang D, et al. Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies. ACS Cent Sci. 2025 Apr 14;11 (5) :704-718.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SIRT3

• CAS Number:

  433953-86-7