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SKLB-D18

CAT: 0013-GTR19258231-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258231-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKLB-D18 is a potent and selective inhibitor of ERK1/2 and ERK5, with IC50 values of 38.69, 40.12, and 59.72 nM, respectively. It also serves as an autophagy agonist, influencing mTOR/p70S6K and NCOA4-mediated ferroptosis, potentially mitigating multidrug resistance. SKLB-D18 demonstrates significantly superior efficacy against triple-negative breast cancer (TNBC) in both in vitro and in vivo studies.
Field of Research
Cell Biology, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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