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SKLB-0124

CAT: 0013-GTR19280539-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19280539-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKLB-0124 is a potent degrader of PRMT6, exhibiting DC50 values of 15.4 μM in HCC827 cells and 16.4 μM in MDA-MB-435 cells. It does not degrade PRMT1 or PRMT8. SKLB-0124 has an IC50 value of 1.6 μM for PRMT6. It induces proteasome-dependent degradation of PRMT6 and significantly inhibits cell proliferation. Additionally, SKLB-0124 effectively induces apoptosis and cell cycle arrest, making it suitable for research in lung cancer and breast cancer.
CAS Number
3065966-31-3
Smiles
O=C (NC1=CC=C (C=C1) C=2C=NC=C (C2) CN (C) CCNC) CCCNC (=O) CC34CC5CC (CC (C5) C3) C4
Molecular Formula
C32H45N5O2
Molecular Weight
531.75
Notes
For research use only.

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