ATX-0126

• Description:

  ATX-0126 (ATX 100) is an ionizable lipid based on thiocarbamate. ATX-0126 can be involved in the formation of lipid nanoparticles and is used in research such as nucleic acid delivery[1][2].

• Product Name Alternative:

  ATX 100

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319

• Target:

  Biochemical Assay Reagents; Liposome

• Type:

  Oligonucleotides

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/mrna-encapsulating-lipid-excipient-1.html

• Purity:

  99.94

• Solubility:

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 20 mg/mL (ultrasonic)

• Smiles:

  O=C(N(CCCC(OC(CCCCCCC)CCCCCCC)=O)CCCC(OC(CCCCCCC)CCCCCCC)=O)SCCCN(C)C

• Molecular Formula:

  C44H86N2O5S

• Molecular Weight:

  755.23

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Kumar Rajappan, et al. Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles. Org. Process Res. Dev. 2021, 25, 6, 1383-1390.|[2]Preparation of ionizable cationic lipids for RNA delivery. US20180170866A1

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  No Development Reported

• CAS Number:

  [2230647-37-5]