ATX-0126

• Description :

  ATX-0126 (ATX 100) is an ionizable lipid based on thiocarbamate. ATX-0126 can be involved in the formation of lipid nanoparticles and is used in research such as nucleic acid delivery[1][2].

• CAS Number :

  [2230647-37-5]

• Product Name Alternative :

  ATX 100

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319

• Target :

  Biochemical Assay Reagents; Liposome

• Type :

  Oligonucleotides

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/mrna-encapsulating-lipid-excipient-1.html

• Purity :

  99.94

• Solubility :

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 20 mg/mL (ultrasonic)

• Smiles :

  O=C(N(CCCC(OC(CCCCCCC)CCCCCCC)=O)CCCC(OC(CCCCCCC)CCCCCCC)=O)SCCCN(C)C

• Molecular Formula :

  C44H86N2O5S

• Molecular Weight :

  755.23

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Kumar Rajappan, et al. Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles. Org. Process Res. Dev. 2021, 25, 6, 1383-1390.|[2]Preparation of ionizable cationic lipids for RNA delivery. US20180170866A1

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported