RegisterLogin

SKLB-D18

CAT: 0804-HY-173119-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-173119-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SKLB-D18 is a potent and selective inhibitor of ERK1/2 and ERK5, with IC50s of 38.69, 40.12 and 59.72 nM, respectively. SKLB-D18 is also an autophagy agonist, plays a role in mTOR/p70S6K and NCOA4-mediated ferroptosis, which may mitigate multidrug resistance. SKLB-D18 exhibits significantly superior efficacy in vitro and in vivo against triple-negative breast cancer (TNBC) [1].
UNSPSC
12352005
Target
Autophagy; ERK
Related Pathways
Autophagy; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CN(C)CC1=CC=CC(NC2=NC(C3=CSC(C(NN4CCOCC4)=O)=C3)=C(Cl)C=N2)=C1
Molecular Formula
C22H25ClN6O2S
Molecular Weight
472.99
References & Citations
[1]Xiao H, et, al. A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy. Signal Transduct Target Ther. 2025 Feb 20;10 (1) :70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-18947-01SKLB-23bb
HY-173572-01SKLB-11A
HY-176848-01SKLB-Y13
HY-177497SKLB-03220
HY-178114SKLB-0124
HY-120429-01SKLB-163
HY-144217-01SKLB-197
HY-122860SKLB-C05
HY-178102SKLB-0266
HY-144501-01D18

Alternative Products

CatalogName
T206864-01SKLB-D18
M10442-01SKLB 610
M27829-01SKLB-163
MBS3842805-01SKLB-23bb
T34656-01SKLB 1028
TRC-S555010-250MGSKLB-1028
MBS5804978SKLB-197
T207811-01SKLB-03220
T210843-01SKLB-11A

Popular Products