PRMT5-IN-35

• Description:

  PRMT5-IN-35 (Compound 87) is a potent, selective and orally active PRMT5 inhibitor with an IC50 value of 1 nM. PRMT5-IN-35 can be used in cancer research[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/prmt5-in-35.html

• Purity:

  99.63

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@@H] (O) [C@H] (N2C3=NC=NC (N) =C3C=C2) O[C@@H]1[C@H] (O) C4=CC=C (Cl) C=C4

• Molecular Formula:

  C17H17ClN4O4

• Molecular Weight:

  376.79

• References & Citations:

  [1]Ferrarotto R, et al. PRT543, a protein arginine methyltransferase 5 inhibitor, in patients with advanced adenoid cystic carcinoma: An open-label, phase I dose-expansion study. Oral Oncol. 2024 Feb;149:106634.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1989620-03-2