CDD-2212

• Description :

  CDD-2212 is a STK33 inhibitor, with a Kd of 1.9 nM and an IC50 of 999 nM. CDD-2212 has relatively weak inhibitory effects on off-target kinases, with IC50 values of 3223 nM for CLK1, 1555 nM for CLK2, 5884 nM for CLK4, and 1093 nM for RET. CDD-2212 can be used for the study of contraception[1].

• Target :

  RET; STK33

• Related Pathways :

  Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

• Field of Research :

  Others

• Smiles :

  O=C(N1C[C@H](CC1)N(C)C)C2=CC=C3C(C(C#CC4=C(C5=CC=CC=C5)C=CC=C4)=NN3)=C2

• Molecular Formula :

  C28H26N4O

• Molecular Weight :

  434.53

• References & Citations :

  [1]Ku AF, et al. Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 May 24;384 (6698) :885-890.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3086535-52-3]