HUP-46

• Description:

  HUP-46 is a BBB-penatrable modulator of αSyn dimerization and autophagy. HUP-46 reduces the ratio of pPP2A/PP2A, increases the autophagy marker LC3BII levels, and decreases αSyn dimerization. HUP-46 can be used for research of neurodegenerative diseases[1].

• UNSPSC:

  12352005

• Target:

  Atg8/LC3; Autophagy; α-synuclein

• Related Pathways:

  Autophagy; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  CC1=C(N2[C@@H](CCC2)C#N)SC(CCCC3=CC=CC=C3)=N1

• Molecular Formula:

  C18H21N3S

• Molecular Weight:

  311.44

• References & Citations:

  [1]Pätsi HT, et al. 5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions. J Med Chem. 2024 Apr 11;67 (7) :5421-5436.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3007689-83-7]