HUP-55

CAT: 0931-MF-0100294-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0100294-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others
Related Pathways
Others
Bioactivity
HUP-55 is a prolyl endopeptidase inhibitor with an IC50 of 5 nM, shown to mitigate ?-synuclein dimerization in Neuro2a cells, stimulate autophagy in HEK293 cells, and lower hydrogen peroxide-evoked reactive oxygen species (ROS) production in SH-SY5Y cells at a 10 µM concentration. Additionally, administration of HUP-55 at a dosage of 10 mg/kg reduces ipsilateral paw use and diminishes striatal oligomeric ?-synuclein concentrations in a Parkinson's disease mouse model, which is induced through adenoviral vector-mediated overexpression of ?-synuclein (AAV-?Syn) .
Smiles
CC1=C(N2[C@H](C#N)CCC2)OC(CCCC3=CC=CC=C3)=N1
Molecular Formula
C18H21N3O
Molecular Weight
295.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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