HUP-55

CAT: 0931-T83875-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T83875-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Others

Related Pathways

Others

Bioactivity

HUP-55 is a prolyl endopeptidase inhibitor with an IC50 of 5 nM, shown to mitigate α-synuclein dimerization in Neuro2a cells, stimulate autophagy in HEK293 cells, and lower hydrogen peroxide-evoked reactive oxygen species (ROS) production in SH-SY5Y cells at a 10 μM concentration. Additionally, administration of HUP-55 at a dosage of 10 mg/kg reduces ipsilateral paw use and diminishes striatal oligomeric α-synuclein concentrations in a Parkinson's disease mouse model, which is induced through adenoviral vector-mediated overexpression of α-synuclein (AAV-αSyn) .

Smiles

CC1=C(N2[C@H](C#N)CCC2)OC(CCCC3=CC=CC=C3)=N1

Molecular Formula

C18H21N3O

Molecular Weight

295.38

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-169831	HUP-55
ARC0345	HuP-T4
HY-176749	HUP-46
ABC-TC497S	HuP-T3
GTR17975915	Hup Antibody
CL-1163	HuP-T3 Cell Line
RWT-725	HuP-T4 Cell Line
CM-1163	HuP-T3 Cell Complete Medium
JH168456	55
BA4725-5	MZP-55

HUP-55

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