HUP-55

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  HUP-55 is a prolyl endopeptidase inhibitor with an IC50 of 5 nM, shown to mitigate ?-synuclein dimerization in Neuro2a cells, stimulate autophagy in HEK293 cells, and lower hydrogen peroxide-evoked reactive oxygen species (ROS) production in SH-SY5Y cells at a 10 µM concentration. Additionally, administration of HUP-55 at a dosage of 10 mg/kg reduces ipsilateral paw use and diminishes striatal oligomeric ?-synuclein concentrations in a Parkinson's disease mouse model, which is induced through adenoviral vector-mediated overexpression of ?-synuclein (AAV-?Syn) .

• Smiles :

  CC1=C(N2[C@H](C#N)CCC2)OC(CCCC3=CC=CC=C3)=N1

• Molecular Formula :

  C18H21N3O

• Molecular Weight :

  295.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C