LSD1-IN-46

CAT: 0804-HY-179339Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179339Size:1 Each
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Description
LSD1-IN-46 is a potent and orally active Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.082 μM. LSD1-IN-46 interrupts the β-catenin-mediated transcriptional program, thereby suppressing the stemness of gastric cancer cells. LSD1-IN-46 exhibits strong anti-tumor activity. LSD1-IN-46 can be used for the research of gastric cancer[1].
CAS Number
[2982716-97-0]
UNSPSC
12352005
Target
Histone Demethylase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
CN(C)C(CC1)CCN1CCCN2C3=C(C=CC=C3)OC4=CC=CC=C24
Molecular Formula
C22H29N3O
Molecular Weight
351.49
References & Citations
[1]Dai XJ, et al. Identification of Novel Phenoxazine-Derived LSD1 Inhibitors Suppressing Gastric Cancer Stemness by β-Catenin Transcriptional Regulation. J Med Chem. 2025;68 (21) :22896-22917.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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