LSD1-IN-46

• Description :

  LSD1-IN-46 is a potent and orally active Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.082 μM. LSD1-IN-46 interrupts the β-catenin-mediated transcriptional program, thereby suppressing the stemness of gastric cancer cells. LSD1-IN-46 exhibits strong anti-tumor activity. LSD1-IN-46 can be used for the research of gastric cancer[1].

• CAS Number :

  [2982716-97-0]

• UNSPSC :

  12352005

• Target :

  Histone Demethylase

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Smiles :

  CN(C)C(CC1)CCN1CCCN2C3=C(C=CC=C3)OC4=CC=CC=C24

• Molecular Formula :

  C22H29N3O

• Molecular Weight :

  351.49

• References & Citations :

  [1]Dai XJ, et al. Identification of Novel Phenoxazine-Derived LSD1 Inhibitors Suppressing Gastric Cancer Stemness by β-Catenin Transcriptional Regulation. J Med Chem. 2025;68 (21) :22896-22917.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  KDM1/LSD1