RegisterLogin

TEPP-46

CAT: 0804-HY-18657-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18657-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR[1][2][3].
CAS Number
[1221186-53-3]
Product Name Alternative
ML-265
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TEPP-46.html
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(N(C)C2=C3SC(S(C)=O)=C2)=C3C=NN1CC4=CC=CC(N)=C4
Molecular Formula
C17H16N4O2S2
Molecular Weight
372.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Anastasiou D, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct;8 (10) :839-847.|[2]Palsson-McDermott EM, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21 (1) :65-80.|[3]Goran Hamid Mohammad, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel) . 2019 Sep 16;11 (9) :1372.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-157674HSD17B13-IN-46
HY-179339LSD1-IN-46
HY-150597HDAC-IN-46
HY-157114ICMT-IN-46
HY-144794EGFR-IN-46
HY-48869-01PI3K-IN-46
HY-N12388AChE-IN-46
HY-175771STAT3-IN-46
HY-176174SCDK2-IN-46
HY-179619Tyrosinase-IN-46

Alternative Products

CatalogName
T7214-01TEPP-46
7809/10TEPP 46
A16279-1TEPP-46 1mg
A16279-5TEPP-46 5mg
A16279-25TEPP-46 25mg
A16279-100TEPP-46 100mg
A16279-500TEPP-46 500mg
C12586-01TEPP-46 (ML265)
A16279-50TEPP-46 50mg
A16279-10TEPP-46 10mg

Popular Products