HUP-55

• Description:

  HUP-55 is a prolyl endopeptidase inhibitor (IC50 = 5 nM) . HUP-55 reduces the dimerization of α-synuclein in Neuro2a cells and induces autophagy (Autophagy) in HEK293 cells. It also decreases the increase in reactive oxygen species (ROS) production induced by hydrogen peroxide in SH-SY5Y cells at a concentration of 10 μM. In a mouse Parkinson’s disease model, HUP-55 (10 mg/kg) improves motor function (reduces the use frequency of the impaired paw) and decreases the levels of harmful oligomers of α-synuclein in the striatum caused by overexpression of α-synuclein[1].

• UNSPSC:

  12352005

• Target:

  α-synuclein

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  CC1=C(N2[C@@H](CCC2)C#N)OC(CCCC3=CC=CC=C3)=N1

• Molecular Formula:

  C18H21N3O

• Molecular Weight:

  295.38

• References & Citations:

  [1]Kilpeläinen TP, et al. Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease. J Med Chem. 2023 Jun 8;66 (11) :7475-7496.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  α-synuclein Aggregation

• CAS Number:

  [3006795-68-9]