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HUP-55

CAT: 0804-HY-169831Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169831Size:1 Each
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Description
HUP-55 is a prolyl endopeptidase inhibitor (IC50 = 5 nM) . HUP-55 reduces the dimerization of α-synuclein in Neuro2a cells and induces autophagy (Autophagy) in HEK293 cells. It also decreases the increase in reactive oxygen species (ROS) production induced by hydrogen peroxide in SH-SY5Y cells at a concentration of 10 μM. In a mouse Parkinson’s disease model, HUP-55 (10 mg/kg) improves motor function (reduces the use frequency of the impaired paw) and decreases the levels of harmful oligomers of α-synuclein in the striatum caused by overexpression of α-synuclein[1].
CAS Number
3006795-68-9
UNSPSC
12352005
Target
α-synuclein
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC1=C(N2[C@@H](CCC2)C#N)OC(CCCC3=CC=CC=C3)=N1
Molecular Formula
C18H21N3O
Molecular Weight
295.38
References & Citations
[1]Kilpeläinen TP, et al. Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease. J Med Chem. 2023 Jun 8;66 (11) :7475-7496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

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