Antimalarial agent 51

• Description:

  Antimalarial agent 51 (Compound 2) is an orally active antimalarial compound. Antimalarial agent 51 blocks nutrient uptake by Plasmodium by inhibiting the plasmodium surface anion channel (PSAC) . Antimalarial agent 51 significantly inhibits the growth of Plasmodium under nutrient-restricted conditions. Combination of antimalarial agent 51 with the residual transport inhibitor PRT-2 can enhance the antimalarial effect. Antimalarial agent 51 can be used in the study of malaria targeting the PSAC channel[1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C (N (C1) CC[C@@]21C[C@@H] (NC3=NC=NC=C3) C2) C4=CC5=C (C=CC=C5) N4

• Molecular Formula:

  C20H21N5O

• Molecular Weight:

  347.41

• References & Citations:

  [1]Molina I, et al. The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels. Cell Chem Biol. 2025 May 21:S2451-9456 (25) 00136-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported