DNMT/HDAC-IN-2

• Description:

  DNMT/HDAC-IN-2 (Compound Y7) is a DNMT and HDAC inhibitor with IC50 values for DNMT1, HDAC1, and HDAC6 of 365, 0.2, and 8.91 nM respectively. DNMT/HDAC-IN-2 inhibits the proliferation of breast cancer cells. DNMT/HDAC-IN-2 significantly reduces tumor growth in xenografts and transgenic breast cancer mouse models. DNMT/HDAC-IN-2 can be used for the study of breast cancer[1].

• UNSPSC:

  12352005

• Target:

  DNA Methyltransferase; HDAC

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  COC1=C(C=C(C2=C1)N=C(C=C2NC3CCN(CC3)C)C4=CC=C(O4)C)OCCCCCCC(NO)=O

• Molecular Formula:

  C28H38N4O5

• Molecular Weight:

  510.63

• References & Citations:

  [1]Lin H, et al. Design, Synthesis, and Biological Evaluation of Quinoline-Based Hydroxamic Acid Derivatives as Dual DNMT and HDAC Inhibitors with Potent Anti-Breast Cancer Activity. J Med Chem. 2025 Sep 25;68 (18) :19022-19040.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  DNMT1; HDAC1; HDAC6

• CAS Number:

  [2548725-57-9]