P-gp-IN-30

CAT: 0931-MF-0118709-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118709-01Size:10 mg
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CAS Number
2761881-65-4
Target
P-gp
Related Pathways
Neuroscience|||Membrane transporter/Ion channel
Bioactivity
P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC) .
Smiles
C(OCC)(=O)C1(C(OCC)=O)[C@@]2([C@@H]([C@H](N1)C=3[C@@]4([C@](CC3)(C(C(OC)=O)=CO[C@H]4OC)[H])[H])C5=CC=CC=C5)C=6C(NC2=O)=CC=CC6
Molecular Formula
C34H36N2O9
Molecular Weight
616.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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