P-gp-IN-31

CAT: 0931-MF-0119429-01Size: 10 mgDry Ice: NoHazardous: No

CAT#:0931-MF-0119429-01Size:10 mg

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PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Target

P-gp|||Apoptosis

Related Pathways

Neuroscience|||Membrane transporter/Ion channel|||Apoptosis

Bioactivity

P-gp-IN-31 is an inhibitor of P-glycoprotein (P-gp) with IC50 values of 0.42 ?M for KB cells and 0.43 ?M for MDR KBvin cells. This compound effectively overcomes P-gp mediated drug efflux, exhibiting collateral sensitivity through P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis (apoptosis), and arrests the cell cycle in the G2/M phase. It is applicable in cancer research, particularly for multidrug-resistant (MDR) malignancies.

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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P-gp-IN-31

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