BMS-986463

• Description :

  BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader. BMS-986463 significantly inhibits tumor regression and reduces the level of phospho-CDK2. BMS-986463 can be used for advanced malignant solid tumors like non-small cell lung cancer (NSCLC) research[1].

• UNSPSC :

  12352005

• Target :

  Wee1

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Purity :

  99.51

• Solubility :

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1CC[C@@H](C(N1)=O)N2CC3=CC(O[C@H]4CCN(C4)CC5=CC(F)=C6N=C(C=CC6=C5)C7CCOCC7)=CC=C3C2=O

• Molecular Formula :

  C32H33FN4O5

• Molecular Weight :

  572.63

• References & Citations :

  [1]Jennifer R, et al. Discovery of a first-in-class molecular glue degrader of WEE1 kinase, BMS-986463, for the treatment of advanced malignant solid tumors. ACS. 2025 Aug 20.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3025467-07-3]