RegisterLogin

BMS-986449

CAT: 0804-HY-173630-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-173630-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors[1].
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=NC(C2=C(F)C([C@@H](C)N([C@H]3CCC(NC3=O)=O)C4=O)=C4C=C2)=CC(C)=C1C
Molecular Formula
C21H21FN4O3
Molecular Weight
396.41
References & Citations
[1]Barnes M J. Selective degradation of Helios induces Treg cell reprogramming and enhanced antitumor immunity[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 2249-2249.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IKZF2; IKZF4

Related Products

CatalogName
HY-145373BMS-986143
HY-172736-01BMS-986458
HY-119886BMS-986169
HY-150787BMS-986339
HY-P10375-01BMS-986189
HY-139396-01BMS-986299
HY-139204-01BMS-986242
HY-131905S-01BMS-986144
HY-171792BMS-986497
HY-175742-01BMS-986470

Alternative Products

CatalogName
T204091-01BMS-986449
MBS386661-01BMS-806 (BMS 378806)
A11201-1BMS-806 (BMS 378806) 1mg
A11201-2BMS-806 (BMS 378806) 2mg
A11201-500BMS-806 (BMS 378806) 500mg
A11201-25BMS-806 (BMS 378806) 25mg
MBS3616196-01BMS 193885
MBS3607783-01BMS-833923
MBS3607487-01BMS-378806
MBS3602996-01BMS-986195

Popular Products