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BMS-986497

CAT: 0804-HY-171792Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171792Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-986497 (ORM-6151) is a CD33-targeted antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells, inducing GSPT1 protein degradation. BMS-986497 is promising for research of acute myeloid leukemia (AML) [1][2].
Product Name Alternative
ORM-6151
UNSPSC
12352211
Target
Transmembrane Glycoprotein
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[BMS-986497]
References & Citations
[1]Li X, et al. Myelodysplastic Neoplasms (MDS) : Pathogenesis and Therapeutic Prospects[J]. Biomolecules, 2025, 15 (6) : 761.|[2]Palacino J, et al. ORM-6151: a first-in-class CD33-antibody enabled GSPT1 degrader for AML[J]. Cancer Research, 2023, 83 (7_Supplement) : 2700-2700.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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