BMS-986497

• Description :

  BMS-986497 (ORM-6151) is a CD33-targeted antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells, inducing GSPT1 protein degradation. BMS-986497 is promising for research of acute myeloid leukemia (AML) [1][2].

• Product Name Alternative :

  ORM-6151

• UNSPSC :

  12352211

• Target :

  Transmembrane Glycoprotein

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  [BMS-986497]

• References & Citations :

  [1]Li X, et al. Myelodysplastic Neoplasms (MDS) : Pathogenesis and Therapeutic Prospects[J]. Biomolecules, 2025, 15 (6) : 761.|[2]Palacino J, et al. ORM-6151: a first-in-class CD33-antibody enabled GSPT1 degrader for AML[J]. Cancer Research, 2023, 83 (7_Supplement) : 2700-2700.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported