BMS-986470

• Description :

  BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research[1].

• CAS Number :

  [3036554-12-5]

• UNSPSC :

  12352005

• Target :

  Histone Acetyltransferase; Ligands for E3 Ligase; Molecular Glues

• Related Pathways :

  Epigenetics; PROTAC

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Smiles :

  CC1=NC=CC(C2=CC3=C(N(C(CC3)=O)C)C=C2NC4=CC=CC5=C4C(N(C5=O)[C@H]6CCC(NC6=O)=O)=O)=C1

• Molecular Formula :

  C29H25N5O5

• Molecular Weight :

  523.54

• References & Citations :

  [1]Rychak E, et al. Development of a ZBTB7A and Wiz Dual Degrading, HbF-Activating CELMoD™ for the Treatment of Sickle Cell Disease[J]. Blood, 2024, 144: 169.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported