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BMS-986470

CAT: 0804-HY-175742-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175742-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research[1].
CAS Number
3036554-12-5
UNSPSC
12352005
Target
Histone Acetyltransferase; Ligands for E3 Ligase; Molecular Glues
Related Pathways
Epigenetics; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CC1=NC=CC(C2=CC3=C(N(C(CC3)=O)C)C=C2NC4=CC=CC5=C4C(N(C5=O)[C@H]6CCC(NC6=O)=O)=O)=C1
Molecular Formula
C29H25N5O5
Molecular Weight
523.54
References & Citations
[1]Rychak E, et al. Development of a ZBTB7A and Wiz Dual Degrading, HbF-Activating CELMoD™ for the Treatment of Sickle Cell Disease[J]. Blood, 2024, 144: 169.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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