STING agonist-46

• Description :

  STING agonist-46 is an orally active STING agonist. STING agonist-46 activates the STING signaling pathway, promoting phosphorylation of TBK1 and IRF3, and secretion of IFN-β and IP-10. STING agonist-46 directly binds to STING and increases its thermal stability. STING agonist-46 demonstrates potent anti-tumor efficacy in B16F10, CT26, and 4T1 mouse models. STING agonist-46 can be used for cancer immunotherapy studies[1].

• UNSPSC :

  12352100

• Target :

  STING

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  O=C(CCC(ONC(C)C)=O)C1=CC2=CC(OC)=C(C=C2S1)OC

• Molecular Formula :

  C17H21NO5S

• Molecular Weight :

  351.42

• References & Citations :

  [1]Shen A, et al. Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists. Eur J Med Chem. 2022 Nov 5;241:114627.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3033532-05-4]