STING agonist-46

CAT: 0804-HY-175714Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175714Size:1 Each
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Description
STING agonist-46 is an orally active STING agonist. STING agonist-46 activates the STING signaling pathway, promoting phosphorylation of TBK1 and IRF3, and secretion of IFN-β and IP-10. STING agonist-46 directly binds to STING and increases its thermal stability. STING agonist-46 demonstrates potent anti-tumor efficacy in B16F10, CT26, and 4T1 mouse models. STING agonist-46 can be used for cancer immunotherapy studies[1].
CAS Number
[3033532-05-4]
UNSPSC
12352100
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(CCC(ONC(C)C)=O)C1=CC2=CC(OC)=C(C=C2S1)OC
Molecular Formula
C17H21NO5S
Molecular Weight
351.42
References & Citations
[1]Shen A, et al. Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists. Eur J Med Chem. 2022 Nov 5;241:114627.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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