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SOS1-IN-21

CAT: 0804-HY-175326Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175326Size:1 Each
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Description
SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer[1].
CAS Number
2767633-04-3
UNSPSC
12352005
Target
SOS1
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(O)(C)C(F)(F)C1=CC=CC([C@H](NC2=C3C=C(OCCOC)C(OC)=CC3=NC(C)=N2)C)=C1F
Molecular Formula
C25H30F3N3O4
Molecular Weight
493.52
References & Citations
[1]Lv Y, et al. A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor. J Med Chem. 2024 Feb 22;67 (4) :2487-2511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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