MGD-22

• Description :

  MGD-22, a molecular glue, is an orally active IKZF1/2/3 degrader with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. MGD-22 exhibits extremely potent anti-proliferative activity against diverse hematological cancer cells. MGD-22 induces apoptosis in cancer cells. MGD-22 demonstrates potent anti-tumor efficacy in mice bearing NCI-H929 xenografts or WSU-DLCL-2 xenografts. MGD-22 can be used for the study of hematological cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL) [1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; IKZF Family; Molecular Glues

• Related Pathways :

  Apoptosis; Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(N1)C(N2N(CC3=C(C=CC=C3C2=O)NCC4=CC=C(CN5CCN(CC5)C6=CC=C(C=C6)C#N)C=C4)C)CCC1=O

• Molecular Formula :

  C33H35N7O3

• Molecular Weight :

  577.68

• References & Citations :

  [1]Wei T, et al. Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers. J Med Chem. 2025 Aug 14;68 (15) :16237-16259.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IKZF1; IKZF2; IKZF3

• CAS Number :

  [2991818-12-1]