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MGD-22

CAT: 0013-GTR19264813-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264813-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MGD-22 is a molecular glue and orally active degrader of IKZF1/2/3, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. It exhibits strong anti-proliferative activity against various hematological cancer cells and induces cell apoptosis (apoptosis) . MGD-22 demonstrates significant anti-tumor efficacy in mice with NCI-H929 or WSU-DLCL-2 xenografts. This compound is useful for researching blood cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL) .
CAS Number
2991818-12-1
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Smiles
N#CC1=CC=C (C=C1) N2CCN (CC3=CC=C (C=C3) CNC4=CC=CC=5C (=O) N (N (C) CC45) C6C (=O) NC (=O) CC6) CC2
Molecular Formula
C33H35N7O3
Molecular Weight
577.68
Storage Conditions
-20°C
Notes
For research use only.

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