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MGD-28

CAT: 0931-T201415-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0931-T201415-01Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2991818-13-2
Target
IKZF|||Casein Kinase
Related Pathways
Immunology/Inflammation|||Stem Cells|||Metabolism
Purity
0.9939
Bioactivity
MGD-28 is a potent, orally active Cullin-CRBN-dependent IKZF family protein degrader that dose-dependently degrades IKZF1 (Ikaros), IKZF2 (Helios), and IKZF3 (Aiolos) at nanomolar strengths.MGD-28 also degrades CK1?, and has shown antiproliferative activity against a variety of hematologic cancer cell lines showing antiproliferative activity in vitro and antitumor effects in in vivo assays, and is commonly used in multiple myeloma (MM) and hematological disorders.
Smiles
N#CC1=CC=C(C=C1F)N2CCN(CC3=CC=C(C=C3)CNC4=CC=CC=5C(=O)N(N(C)CC45)C6C(=O)NC(=O)CC6)CC2
Molecular Formula
C33H34FN7O3
Molecular Weight
595.67
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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