MGD-28

• Target:

  IKZF|||Casein Kinase

• Related Pathways:

  Immunology/Inflammation|||Stem Cells|||Metabolism

• Purity:

  0.9939

• Bioactivity:

  MGD-28 is a potent, orally active Cullin-CRBN-dependent IKZF family protein degrader that dose-dependently degrades IKZF1 (Ikaros), IKZF2 (Helios), and IKZF3 (Aiolos) at nanomolar strengths.MGD-28 also degrades CK1?, and has shown antiproliferative activity against a variety of hematologic cancer cell lines showing antiproliferative activity in vitro and antitumor effects in in vivo assays, and is commonly used in multiple myeloma (MM) and hematological disorders.

• Smiles:

  N#CC1=CC=C (C=C1F) N2CCN (CC3=CC=C (C=C3) CNC4=CC=CC=5C (=O) N (N (C) CC45) C6C (=O) NC (=O) CC6) CC2

• Molecular Formula:

  C33H34FN7O3

• Molecular Weight:

  595.67

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2991818-13-2