MGD-28

• Target :

  IKZF|||Casein Kinase

• Related Pathways :

  Immunology/Inflammation|||Stem Cells|||Metabolism

• Purity :

  0.9939

• Bioactivity :

  MGD-28 is a potent, orally active Cullin-CRBN-dependent IKZF family protein degrader that dose-dependently degrades IKZF1 (Ikaros), IKZF2 (Helios), and IKZF3 (Aiolos) at nanomolar strengths.MGD-28 also degrades CK1?, and has shown antiproliferative activity against a variety of hematologic cancer cell lines showing antiproliferative activity in vitro and antitumor effects in in vivo assays, and is commonly used in multiple myeloma (MM) and hematological disorders.

• Smiles :

  N#CC1=CC=C(C=C1F)N2CCN(CC3=CC=C(C=C3)CNC4=CC=CC=5C(=O)N(N(C)CC45)C6C(=O)NC(=O)CC6)CC2

• Molecular Formula :

  C33H34FN7O3

• Molecular Weight :

  595.67

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2991818-13-2