MGD-4

• Description:

  MGD-4 is an orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  IKZF Family

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mgd-4.html

• Purity:

  95.86

• Smiles:

  O=C1N (C2C (NC (CC2) =O) =O) N (C) CC3=C (N) C=CC=C31

• Molecular Formula:

  C14H16N4O3

• Molecular Weight:

  288.30

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IKZF1; IKZF2; IKZF3

• CAS Number:

  2991817-99-1