MGD-4

• Description :

  MGD-4 is an orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  IKZF Family

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mgd-4.html

• Purity :

  95.86

• Smiles :

  O=C1N(C2C(NC(CC2)=O)=O)N(C)CC3=C(N)C=CC=C31

• Molecular Formula :

  C14H16N4O3

• Molecular Weight :

  288.30

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IKZF1; IKZF2; IKZF3

• CAS Number :

  [2991817-99-1]