MGD-28

• Description :

  MGD-28 is a potent, orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM) . MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].

• UNSPSC :

  12352211

• Target :

  Casein Kinase; IKZF Family

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mgd-28.html

• Purity :

  99.73

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CN(N(C1C(NC(CC1)=O)=O)C2=O)CC(C2=CC=C3)=C3NCC(C=C4)=CC=C4CN(CC5)CCN5C6=CC(F)=C(C#N)C=C6

• Molecular Formula :

  C33H34FN7O3

• Molecular Weight :

  595.67

• References & Citations :

  [1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CK1; IKZF1; IKZF2; IKZF3

• CAS Number :

  [2991818-13-2]