MGD-28

• Description:

  MGD-28 is a potent, orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM) . MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].

• UNSPSC:

  12352211

• Target:

  Casein Kinase; IKZF Family

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mgd-28.html

• Purity:

  99.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CN (N (C1C (NC (CC1) =O) =O) C2=O) CC (C2=CC=C3) =C3NCC (C=C4) =CC=C4CN (CC5) CCN5C6=CC (F) =C (C#N) C=C6

• Molecular Formula:

  C33H34FN7O3

• Molecular Weight:

  595.67

• References & Citations:

  [1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CK1; IKZF1; IKZF2; IKZF3

• CAS Number:

  2991818-13-2