MGD-28

CAT: 0804-HY-168615-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-168615-01Size:5 mg
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Description
MGD-28 is a potent, orally active, Cereblon (CRBN) -dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM) . MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].
CAS Number
[2991818-13-2]
UNSPSC
12352211
Target
Casein Kinase; IKZF Family
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mgd-28.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(N(C1C(NC(CC1)=O)=O)C2=O)CC(C2=CC=C3)=C3NCC(C=C4)=CC=C4CN(CC5)CCN5C6=CC(F)=C(C#N)C=C6
Molecular Formula
C33H34FN7O3
Molecular Weight
595.67
References & Citations
[1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17 (1) : 77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; IKZF1; IKZF2; IKZF3

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