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VNT-101

CAT: 0804-HY-175469-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175469-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection[1].
CAS Number
2894060-67-2
UNSPSC
12352005
Target
Influenza Virus
Related Pathways
Anti-infection
Field of Research
Infection
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC[C@]1(COC[C@H](O1)COC2=CC=C(C(C=C3C(N)=O)=C(C(F)(F)F)NC3=O)C=C2)C
Molecular Formula
C21H23F3N2O6
Molecular Weight
456.41
References & Citations
[1]Taft BR, et al. Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein-Protein Interaction. J Med Chem. 2025 Aug 14;68 (15) :16349-16370.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carboxamide
CAS Number2894060-67-2
PubChem CID166486993
IUPAC Name5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carboxamide
Molecular FormulaC21H23F3N2O6
Molecular Weight456.4
XLogP1.5
Topological Polar Surface Area109
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity789
SMILES
C[C@@]1(COC[C@H](O1)COC2=CC=C(C=C2)C3=C(NC(=O)C(=C3)C(=O)N)C(F)(F)F)COC
InChI
InChI=1S/C21H23F3N2O6/c1-20(10-29-2)11-30-8-14(32-20)9-31-13-5-3-12(4-6-13)15-7-16(18(25)27)19(28)26-17(15)21(22,23)24/h3-7,14H,8-11H2,1-2H3,(H2,25,27)(H,26,28)/t14-,20-/m0/s1
InChIKey
HXRWEQWZOYMDOW-XOBRGWDASA-N
Chemical Structure
2D Structure
2D structure of 5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carboxamide
CAS: 2894060-67-2
CID: 166486993
Formula: C21H23F3N2O6
MW: 456.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.4
XLogP31.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass456.15082094
Monoisotopic Mass456.15082094
Topological Polar Surface Area109 Ų
Heavy Atom Count32
Formal Charge0
Complexity789
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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