VNT-101

CAT: 0804-HY-175469-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-175469-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection[1].
CAS Number
[2894060-67-2]
UNSPSC
12352005
Target
Influenza Virus
Related Pathways
Anti-infection
Field of Research
Infection
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC[C@]1(COC[C@H](O1)COC2=CC=C(C(C=C3C(N)=O)=C(C(F)(F)F)NC3=O)C=C2)C
Molecular Formula
C21H23F3N2O6
Molecular Weight
456.41
References & Citations
[1]Taft BR, et al. Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein-Protein Interaction. J Med Chem. 2025 Aug 14;68 (15) :16349-16370.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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