VNT-101

CAT: 0931-T212391-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T212391-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2894060-67-2

Target

Influenza Virus

Related Pathways

Microbiology/Virology

Bioactivity

VNT-101 is an orally active inhibitor of influenza A virus (IAV) . It disrupts NP-NP protein interactions, preventing NP oligomerization and destabilizing the viral ribonucleoprotein (RNP) complex, showing potent antiviral activity against multiple influenza A virus subtypes. In cell-based cytopathic effect (CPE) assays, VNT-101 has an EC50 value of 4-5 nM, while it measures 4-8 nM in neuraminidase (NA) assays and 21-45 nM in ribonucleoprotein (RNP) assays. Demonstrating strong in vivo antiviral efficacy, VNT-101 protects against lethal H1N1 virus infection in mice. VNT-101 is applicable to influenza A virus infection research.

Smiles

C(F)(F)(F)C1=C(C=C(C(N)=O)C(=O)N1)C2=CC=C(OC[C@H]3O[C@](COC)(C)COC3)C=C2

Molecular Formula

C21H23F3N2O6

Molecular Weight

456.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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