VNT-101

• Target :

  Influenza Virus

• Related Pathways :

  Microbiology/Virology

• Bioactivity :

  VNT-101 is an orally active inhibitor of influenza A virus (IAV) . It disrupts NP-NP protein interactions, preventing NP oligomerization and destabilizing the viral ribonucleoprotein (RNP) complex, showing potent antiviral activity against multiple influenza A virus subtypes. In cell-based cytopathic effect (CPE) assays, VNT-101 has an EC50 value of 4-5 nM, while it measures 4-8 nM in neuraminidase (NA) assays and 21-45 nM in ribonucleoprotein (RNP) assays. Demonstrating strong in vivo antiviral efficacy, VNT-101 protects against lethal H1N1 virus infection in mice. VNT-101 is applicable to influenza A virus infection research.

• Smiles :

  C(F)(F)(F)C1=C(C=C(C(N)=O)C(=O)N1)C2=CC=C(OC[C@H]3O[C@](COC)(C)COC3)C=C2

• Molecular Formula :

  C21H23F3N2O6

• Molecular Weight :

  456.41

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2894060-67-2