MG-101

• Description :

  MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer[1].

• Product Name Alternative :

  Calpain inhibitor I; Ac-LLnL-CHO; ALLN

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335

• Target :

  Apoptosis; Proteasome

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MG-101.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(N[C@H](C=O)CCCC)[C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C

• Molecular Formula :

  C20H37N3O4

• Molecular Weight :

  383.53

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Li SZ, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013 Jul 26;437 (2) :325-330.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [110044-82-1]