Mtb-IN-12

• Target:

  Cytochromes P450|||Antibacterial

• Related Pathways:

  Microbiology/Virology|||Metabolism

• Bioactivity:

  Mtb-IN-12 (Compound 5m) is a dual-target inhibitor that acts on the Mycobacterium tuberculosis enzymes CYP125 with a dissociation constant (KD) of 40 nM and an inhibition constant (KI) of 0.1 ?M, and CYP142 with a KD of 160 nM and a KI of 0.05 ?M. It effectively inhibits both drug-sensitive and multidrug-resistant strains of the tuberculosis bacterium, with low toxicity to macrophages, making it useful for studying anti-tuberculosis treatments.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C