Antituberculosis agent-15

• Description:

  Antituberculosis agent-15 (Compound 18c) is a selective antimycobacterial agent with MICs of 0.45 and 0.28 μM for M. tuberculosis H37Rv (ATCC 27294) and its wild-type H37Rv-LP (ATCC 25618), respectively. Antituberculosis agent-15 has potent intracellular inhibitory activities in macrophage infection models with IC50s of 0.16 μM. Antituberculosis agent-15 can be used for tuberculosis research[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  CC1=NC(NCCCC2=CC=CC=C2)=C3C=C(Br)C=CC3=N1

• Molecular Formula:

  C18H18BrN3

• Molecular Weight:

  356.26

• References & Citations:

  [1]Gonçalves GA, et al. Scaffold Hopping Strategy toward New 4‑Aminoquinazolines Active Against Extracellular and Intracellular. ACS Med Chem Lett. 2025 Jun 30;16 (7) :1410-1419.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported