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EGFR-IN-163

CAT: 0804-HY-174231Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174231Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-163 (Compound 13) is a competitive epidermal growth factor receptor (EGFR) inhibitor (IC50=0.079 μM, selective for HER-2 inhibition) . EGFR-IN-163 induces tumor cell apoptosis and cell cycle arrest at G₂/M phase. EGFR-IN-163 is promising for research of estrogen receptor-positive (ER+) breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC(C1=CC(C2=CN(C3=CC=C(OCCCCCCCC)C=C3)N=N2)=NC(C4=CN(C5=CC=C(OCCCCCCCC)C=C5)N=N4)=C1)=O
Molecular Formula
C39H49N7O4
Molecular Weight
679.85
References & Citations
[1]Khalaf Alshamari A, et al. Revealing the Anti-Cancer Potential of 1, 2, 3-Triazole-Isonicotinate Derivatives Targeting EGFR Kinase Inhibition in MCF-7 Cancer Cells: Design, Synthesis, Biological Evaluation, and In Silico Studies[J]. Polycyclic Aromatic Compounds, 2025: 1-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ErbB2/HER2

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