EM-163

• Description:

  EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B) [1].

• UNSPSC:

  12352005

• Target:

  IFNAR; TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/em-163.html

• Purity:

  95.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N1CCCC1) [C@H] (C (C) C) N (CCCC2=CC=CC=C2) C (C3=C[N+] (C) =C (C=C3) C (N (CCCC4=CC=CC=C4) [C@@H] (C (C) C) C (N5CCCC5) =O) =O) =O.[I-]

• Molecular Formula:

  C44H60IN5O4

• Molecular Weight:

  849.88

• References & Citations:

  [1]Kissner TL, et al. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One. 2012;7 (7) :e40773.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1206480-93-4