EM-163

CAT: 0804-HY-163035-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-163035-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B) [1].
CAS Number
[1206480-93-4]
UNSPSC
12352005
Target
IFNAR; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/em-163.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
O=C(N1CCCC1)[C@H](C(C)C)N(CCCC2=CC=CC=C2)C(C3=C[N+](C)=C(C=C3)C(N(CCCC4=CC=CC=C4)[C@@H](C(C)C)C(N5CCCC5)=O)=O)=O.[I-]
Molecular Formula
C44H60IN5O4
Molecular Weight
849.88
References & Citations
[1]Kissner TL, et al. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One. 2012;7 (7) :e40773.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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